Addiction is a multi-factorial disease having psychosocial, genetic, spiritual and metabolic components. The most significant mechanism of this disease process is manifest through neuropsychological insult within the Brain Reward Cascade Model known as REWARD DEFICIENCY SYNDROME (RDS)(1)

(1) Blum, Ken; Braverman, Eric; Holder, Jay;
et al: Reward Deficiency Syndrome A
Biogenetic Model, Journal of Psychoactive
Drugs, Nov. 2000, Vol 32